SPIRIT-Path
Project to develop International Consensus Guidance on the Inclusion of Pathology in Clinical Trial Protocols: The SPIRIT-Path Extension
The SPIRIT initiative aims to help improve the completeness and quality of trial protocols. The evidence-based SPIRIT recommendations were developed using systematic, transparent methodology and broad consultation with 115 experts representing diverse stakeholders involved in the design, funding, conduct, review, and publication of trial protocols.
» Read more about the SPRIT Statement here
The importance of pathology is increasingly being recognised in drug development and conducting clinical trials, from ensuring the correct diagnosis for selecting patients for targeted therapy, platform studies and endpoint validation of pathological complete response.
We therefore feel that an extension to the SPIRIT statement for Pathology will:
- Lead to more comprehensive clinical trial protocols
- Enhance clinical trial design and drug development through early pathology input
- Increase the number and availability of trials-active pathologists by raising the profile of pathologists in clinical trials
Phase 2: refinements to the long-list and removal of duplicate items
Phase 3: an international stakeholder survey;
Phase 4: an international Delphi survey
Phase 5: an international consensus meeting
If you are interested in contributing, please register your interest here:
SPIRIT-Path Core Delivery Group
Member | Role/Area | Institution |
---|---|---|
Dr Tim Kendall | SPIRIT-Path Co-Chair, Pathological Society of Great Britain and Ireland Representative | University of Edinburgh |
Dr Max Robinson | SPIRIT-Path Co-Chair | Newcastle University |
Professor David Harrison | CM-Path Chair | University of St Andrews |
Dr Abeer Shaaban | CM-Path Member | Queen Elizabeth Hospital, Birmingham |
Dr Dan O’Connor | CM-Path Member | MHRA |
Miss Helen Pitman | CM-Path Programme Manager, NCRI Strategic Support | NCRI |
SPIRIT-Path Advisory Group
Member | Role/Area | Institution |
---|---|---|
Dr Owen Driskell | CM-Path Member | NIHR |
Dr Nick West | CM-Path Member | University of Leeds |
Dr Maggie Cheang | CM-Path Member | Institute of Cancer Research |
Prof Keith Hunter | CM-Path Member | University of Sheffield |
Prof Clare Verrill | CM-Path Member | University of Oxford |
Prof David Roberts | RCPath Representative | University of Oxford |
Dr An-Wen Chan | SPIRIT Representative | Women’s College Research Institute, University of Toronto, Canada |
Dr José Palacios Calvo | European Society of Pathology Representative | Hospital Universitario Ramón y Cajal |
Jane Lim | Trainee Representative | Newcastle University |
Emma Kinloch | Consumer representative | Consumer Lead, NCRI |
Daniel Brierley | Delphi Advisor | University of Sheffield |
Gary Middleton | Clinical Advisor | University of Birmingham |